Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development.

Zebrafish Wnt9b Patterns the First Pharyngeal Arch into D-I-V Domains and Promotes Anterior-Medial Outgrowth

Disrupted morphogenesis and growth of the embryonic maxillary jaw lead to oral facial clefting in humans (OFC) and result in an incompletely formed secondary mouth and face. A requirement for Wnt signaling and Wnt9b in particular are postulated in the etiology of OFC from association studies in humans and from animal models. Loss of murine Wnt9b leads to reduced upper jaw (maxillary) outgrowth ...

A SHH-responsive signaling center in the forebrain regulates craniofacial morphogenesis via the facial ectoderm.

Interactions among the forebrain, neural crest and facial ectoderm regulate development of the upper jaw. To examine these interactions, we activated the Sonic hedgehog (SHH) pathway in the brain. Beginning 72 hours after activation of the SHH pathway, growth within the avian frontonasal process (FNP) was exaggerated in lateral regions and impaired in medial regions. This growth pattern is simi...

Upper lip and nose development in mice starts around embryonic day (E) 9.5, when neural crest cells from the dorsal region of the fore- and mid-brain migrate ventrally and form mesenchyme within an unpaired frontonasal prominence rostral to the telencephalon

INTRODUCTION Upper lip and nose development in mice starts around embryonic day (E) 9.5, when neural crest cells from the dorsal region of the foreand mid-brain migrate ventrally and form mesenchyme within an unpaired frontonasal prominence rostral to the telencephalon (Serbedzija et al., 1992; Osumi-Yamashita et al., 1994; Kontges and Lumsden, 1996; Creuzet et al., 2005; Minoux and Rijli, 2010...

Relationship between Changes of Nasal Length and Upper Lip Height during Smile

A new method for maxillary arch form design in cleft lip and palate patients

Introduction: A study on the presentation of a modified beta function formula to predict maxillary arch form in patients with cleft palate (CLP) is of great importance. In order to have this information, this study was done to present a modified beta function formula for predicting upper dental arch of patients with cleft lip and palate (CLP) and to assess its accuracy. Since this information c...